Difference between revisions of "Transmission routes"

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* Several choir-based outbreaks of COVID19 have been observed. The specific risks of singing together, even when respecting 6 feet distance, have not been investigated.
 
* Several choir-based outbreaks of COVID19 have been observed. The specific risks of singing together, even when respecting 6 feet distance, have not been investigated.
 
* A video with observations from Korea provides some insights:
 
* A video with observations from Korea provides some insights:
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==Analysis and interpretation==
 
==Analysis and interpretation==

Revision as of 15:42, 2 May 2020

This page collects observations, interpretations, and consequences for action about Transmission Routes of SARS-CoV2. Please observe the structure of the page, when you add your content. Please use references where possible. Remember to find the relevant page. For example, if your observation is about Sources, please use that page, instead of posting your content here.

What is already known

  • Person to Person Transmission (close contact). [1]
    • Droplet infection
    • Cross-contamination of hands
  • Fomites. [1]
  • No evidence of vertical (mother-child) transmission. [1]
  • Potential of SARS-CoV2 to survive in aerosol. [2]

Feacal-oral transmission?

Observations

  • Some authors report that diarrhea is a common symptom of COVID19. [1]
  • Others report that diarrhea is not common everywhere (5% in China, 17% in Singapore), and may be a coincidental symptom. [3]

Analysis and interpretation

  • The question raises, whether we should anticipate transmission routes as observed with SARS (via sewage overflow and aerosols)
  • Differences in reported frequency in diarrhea may be confounded by difficulty in the assessment. The definition of the symptom may not be standardized between studies. Often, it is also patient-reported, and reporting this symptom may be culturally biassed.

Consequences for action

  • Study fecal-oral transmission routes as risk factors for COVID19

Practical Risk of Aerosols

Observations

  • SARS-CoV2 stability in aerosol was experimentally tested, where authors measure the viability of virus on surfaces, after aerosol nebulizing [2]

Analysis and interpretation

  • Does 'viability on surface' mean that the virus is still (biologically) infectious? I would be hesitant to extrapolate the findings of Doremalen to that conclusion.

Consequences for action

  • Further study infectiousness of aerosols, for example in ferret models?

Choir singing and Corona risk

Observations

  • Several choir-based outbreaks of COVID19 have been observed. The specific risks of singing together, even when respecting 6 feet distance, have not been investigated.
  • A video with observations from Korea provides some insights:

Analysis and interpretation

Consequences for action

References

  1. 1.0 1.1 1.2 1.3 Rothan, Hussin A., and Siddappa N. Byrareddy. "The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak." Journal of Autoimmunity (2020): 102433.
  2. 2.0 2.1 van Doremalen, Neeltje, et al. "Aerosol and surface stability of HCoV-19 (SARS-CoV-2) compared to SARS-CoV-1." medRxiv (2020).
  3. Ong, John, Barnaby Edward Young, and Sharon Ong. "COVID-19 in gastroenterology: a clinical perspective." Gut (2020).