Difference between revisions of "Immune Response"
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| − | This page collects observations, interpretations, and consequences action about | + | This page collects observations, interpretations, and consequences for action about Immune Response against SARS-CoV2. Please observe the structure of the page, when you add your content. Please use references where possible. Remember to find the relevant page. For example, if your observation is about [[Sources]], please use that page, instead of posting your content here. |
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| + | =What is already known= | ||
=Topic 1= | =Topic 1= | ||
| − | + | ==Observations== | |
| − | == | + | * The IL6 inhibitor [https://en.wikipedia.org/wiki/Tocilizumab Tocilizumab] seems to have positive effects in treating COVID19. It has been observed that lymphocytes come back, neutrophils come down. Trials are underway to further study this. <Ref name="TWIV29mar">TWIV This Week in Virology 29 March 2020 https://open.spotify.com/episode/7BEqdjQ8wp4CcG29Qd37LN?si=8lsa9fjuSLWK6DCQJQo7qw</ref> |
| + | ** The COVID19 is often associated with a [https://en.wikipedia.org/wiki/Cytokine_release_syndrome cytokine storm] that is IL1, IL6, IL10 driven. If you block IL6, then you basically block this entire process. <Ref name="TWIV29mar"/> | ||
| + | ** The process of this cytokine storm seems to indicate a maladapted immune response, especially because this is observed after the viral load is already on the way down (day 7-14); this is when the adaptive immune response needs to take over from the innate immune system. Perhaps this is a common mechanism in COVID19, as we see most of the severe deterioration in the period 7-14 days after onset. <Ref name="TWIV29mar"/> | ||
==Analysis and interpretation== | ==Analysis and interpretation== | ||
| − | |||
==Consequences for action== | ==Consequences for action== | ||
=References= | =References= | ||
Latest revision as of 12:28, 30 March 2020
This page collects observations, interpretations, and consequences for action about Immune Response against SARS-CoV2. Please observe the structure of the page, when you add your content. Please use references where possible. Remember to find the relevant page. For example, if your observation is about Sources, please use that page, instead of posting your content here.
Contents
What is already known
Topic 1
Observations
- The IL6 inhibitor Tocilizumab seems to have positive effects in treating COVID19. It has been observed that lymphocytes come back, neutrophils come down. Trials are underway to further study this. [1]
- The COVID19 is often associated with a cytokine storm that is IL1, IL6, IL10 driven. If you block IL6, then you basically block this entire process. [1]
- The process of this cytokine storm seems to indicate a maladapted immune response, especially because this is observed after the viral load is already on the way down (day 7-14); this is when the adaptive immune response needs to take over from the innate immune system. Perhaps this is a common mechanism in COVID19, as we see most of the severe deterioration in the period 7-14 days after onset. [1]
Analysis and interpretation
Consequences for action
References
- ↑ 1.0 1.1 1.2 TWIV This Week in Virology 29 March 2020 https://open.spotify.com/episode/7BEqdjQ8wp4CcG29Qd37LN?si=8lsa9fjuSLWK6DCQJQo7qw
