Pathogenesis - Revision history

Bosmana: /* Clinical characteristics */

2020-04-06T07:05:42Z

‎Clinical characteristics

2020-04-06T06:55:12Z

‎Clinical characteristics

2020-04-06T06:46:54Z

‎What is already known

2020-04-06T06:46:23Z

‎What is already known

2020-04-06T06:46:14Z

‎What is already known

2020-03-30T12:12:41Z

‎Clinical characteristics

2020-03-30T12:09:02Z

‎Clinical characteristics

2020-03-30T12:07:35Z

‎Clinical characteristics

2020-03-30T12:06:26Z

2020-03-29T08:54:52Z

‎What is already known

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 * Viral illness that presents with the full spectrum of most respiratory virus. Some symptoms (and combinations) are more predictive for a positive COVID19-PCR: <Ref name="TWIV29mar">TWIV This Week in Virology 29 March 2020: https://open.spotify.com/episode/7BEqdjQ8wp4CcG29Qd37LN?si=egc0im1eRqy7AMu3H8NKyQ</ref>
 ** Cough + fever + shortness of breath: Triples the base chance of a positive PCR among patients with respiratory illness <Ref>Excerpt from TWIV 29 march: SWAB study, Washington state, USA, among 500+ patients with respiratory symptoms</ref>
-** Anosmia has now been recognized as a typical clinical symptom of SARS-CoV2 infection.
+** Anosmia has now been recognized as a typical clinical symptom of SARS-CoV2 infection.<ref>Hopkins, C., and N. Kumar. 2020. “Loss of Sense of Smell as Marker of COVID-19 Infection.” Retrieved from https://www.entuk.org/sites/default/files/files/Loss%20of%20sense%20of%20smell%20as%20marker%20of%20COVID.pdf</ref>
 * Predictors of severe outcome <Ref name="TWIV29mar"/>
 ** Shortness of breath, (or) fatigue, (or) headache, (or) abdominal pain

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 * Viral illness that presents with the full spectrum of most respiratory virus. Some symptoms (and combinations) are more predictive for a positive COVID19-PCR: <Ref name="TWIV29mar">TWIV This Week in Virology 29 March 2020: https://open.spotify.com/episode/7BEqdjQ8wp4CcG29Qd37LN?si=egc0im1eRqy7AMu3H8NKyQ</ref>
 ** Cough + fever + shortness of breath: Triples the base chance of a positive PCR among patients with respiratory illness <Ref>Excerpt from TWIV 29 march: SWAB study, Washington state, USA, among 500+ patients with respiratory symptoms</ref>
 * Predictors of severe outcome <Ref name="TWIV29mar"/>
 ** Shortness of breath, (or) fatigue, (or) headache, (or) abdominal pain

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 =What is already known=
 * The evidence suggests an association of viral dose with the severity of the disease. However,  the evidence of the relationship is limited by the poor quality of many of the studies, the retrospective nature of the studies, small sample sizes and the potential problem with selection bias. <Ref>SARS-CoV-2 viral load and the severity of COVID-19. [https://www.cebm.net/covid-19/sars-cov-2-viral-load-and-the-severity-of-covid-19/ CEBM Oxford. March 26, 2020]</ref>
 =Clinical characteristics=

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 =What is already known=
 * The evidence suggests an association of viral dose with the severity of the disease. However,  the evidence of the relationship is limited by the poor quality of many of the studies, the retrospective nature of the studies, small sample sizes and the potential problem with selection bias. <Ref>SARS-CoV-2 viral load and the severity of COVID-19. [https://www.cebm.net/covid-19/sars-cov-2-viral-load-and-the-severity-of-covid-19/ CEBM Oxford. March 26, 2020]</ref>
 =Clinical characteristics=

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 =What is already known=
 * The evidence suggests an association of viral dose with the severity of the disease. However,  the evidence of the relationship is limited by the poor quality of many of the studies, the retrospective nature of the studies, small sample sizes and the potential problem with selection bias. <Ref>SARS-CoV-2 viral load and the severity of COVID-19. [https://www.cebm.net/covid-19/sars-cov-2-viral-load-and-the-severity-of-covid-19/ CEBM Oxford. March 26, 2020]</ref>
 =Clinical characteristics=

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 *** 10-20: ICU range
 *** >20: few survivors
 =Asymptomatic infections=

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 ** Oxygen saturation drop
 ** Respiratory rate <20/min (lower risk); >24/min: worse
 ** Neutrophil: Lymphocyte ratios
 *** <3 - good prognosis

← Older revision		Revision as of 08:54, 29 March 2020
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	=What is already known=		=What is already known=
		+	* The evidence suggests an association of viral dose with the severity of the disease. However, the evidence of the relationship is limited by the poor quality of many of the studies, the retrospective nature of the studies, small sample sizes and the potential problem with selection bias. <Ref>SARS-CoV-2 viral load and the severity of COVID-19. [https://www.cebm.net/covid-19/sars-cov-2-viral-load-and-the-severity-of-covid-19/ CEBM Oxford. March 26, 2020]</ref>

	=Asymptomatic infections=		=Asymptomatic infections=